Normal rabbit aqueous humour, fibronectin, and fibroblast conditioned medium are chemoattractant to Tenon's capsule fibroblasts

An antimicrobial effect associated with rabbit primary aqueous humour.

Viability curves were recorded for a variety of bacteria suspended in rabbit primary aqueous humour. Controls included neat rabbit serum, dilute rabbit serum (1/50), dilute heat treated fetal bovine serum (1/50), and balanced salt solution. Rabbit aqueous humour was bactericidal in vitro for Staphylococcus aureus and Pseudomonas aeruginosa. Micrococcus spp, Streptococcus pneumoniae and Escheric...

Growth inhibition and differentiation of human salivary adenocarcinoma cells by medium conditioned with normal human fibroblasts.

The present study demonstrates that normal human fibroblasts (WI-38) exert a profound influence on the growth and differentiation of HSGc-C5, a clonal neoplastic epithelial cell line of human salivary gland origin. Coculture of HSGc-C5 with WI-38 resulted in a slowing of growth and an increase in glycosaminoglycan synthesis by an indirect effect involving a diffusible factor(s). Conditioned med...

Erythromycin in the aqueous humour.

Stimulation of rat hepatocyte fibronectin production by monocyte- conditioned medium is due to interleukin 6

In this report, conditioned media from LPS-stimulated monocytes increased rat hepatocyte production of fibronectin (Fn) in a dose-dependent manner. Preincubation of the conditioned media with anti-IL-6, but not with anti-IL-1 alpha, anti-IL-1 beta, or anti-TNF, completely neutralized the Fn-stimulating activity. 10-100 pg/ml of rIL-6 was sufficient to increase Fn production. Neither IL-1 nor TN...

Aqueous humour vitamin B12 and intramuscular cobalamins.

Previous work on the vitamin B12 content of the aqueous humour (Phillips, Ainley, van Peborgh, Watson-Williams, and Bottomley, I968) suggests that the levels found in a series of mainly elderly patients (mean: 299 pg./ml.) are of the same order as those found in cerebrospinal fluid (mean: 21 pg./ml.) (Kidd, Gould, and Thomas, I963). As an extension of this study, the response of aqueous vitamin...